ESTIMATION OF PRASUGREL HYDROCHLORIDE IN BULK DOSAGE FORM BY UV

Dr. Juluri Krishna Dutta Tejaswi

NRI College of Pharmacy, Krishna district, Vijayawada, Andhra Pradesh, India

ABSTRACT

Prasugrel is used to prevent blood clots in people with recent heart attack or with certain disorders of the heart. To optimize the diluent, various solvents were tested, the use of methanol resulted in no interference at λmax 218nm. The linearity was established by comparing various concentrations and absorbance’s at absorption maximum. The linearity was found in the concentration range of 5 – 30 ppm. The limit of detection and limit of quantization values were found to be 1.209 ppm and 3.664 ppm. This indicates the sensitivity of the method. No interference peaks were found near the λmax during the estimation of the drug by the proposed UV method.

Keywords:

Prasugrel, Acetonitrile, Heart Attack, Methanol