IN VITRO ANTIOXIDANT AND ANTI-DOPAMINERGIC ACTIVITY OF ALKALOID-RICH FRACTION ISOLATED FRO MLEAVES OF MURRAYA KOENIGII

Patil Rupali A*, Langade Padmaja M

Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharm. Edu. & Res, Vidyanagar, Nashik, Maharashtra, India

ABSTRACT

Anti-dopaminergic or dopamine antagonists are preferably used as anti-psychotics, in schizophrenia, bipolar disorders and stimulant psychosis. They are also effective in many other gastrointestinal disorders including nausea and vomiting. Many herbal drugs like digoxin, quinine, morphine, are known for their therapeutic importance. The objective of this study was to use animal models to investigate the impact of Murraya koenigii L. leaves (MK) as an anti-dopaminergic.Pet ether extract of MK (PEMK) and alkaloids isolated from PEMK (AFMK) has shown potent antioxidant activity when tested against invitro antioxidant methods like free radical scavenging by DPPH method, total antioxidant activity by thiocyanate method and H2O2scavenging activity. Significant decreasein the dopaminergic activity was observed in validated animal models like haloperidol-induced catalepsy in mice, apomorphine-induced stereotypic behavior, foot shock-induced aggression and phenobarbitone-induced sleeping behavior. This may be attributed to the presence of carbazole alkaloids having antioxidant potential.

Keywords:

Alkaloids, Anti-dopaminergic, catalepsy, foot-shock-induced aggregation, haloperidol, Murraya koenigii