Chloroform extricate of trianthema portulacastrum, whole plant: an anti-hyperlipidemic in atherogenic diet induced hyperlipidemic rats

Yada Divya*, T. Sivakkumar, M. Sudhakar

Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, telangana state, India

ABSTRACT

Hyperlipidemia is contemplated to be among the considerable risk factor that contributes to the severity as well as incidence of cardiovascular diseases. The Anti hyperlipidemic effect of Chloroform extricate of entire plant Trianthema portulacastrum has been studied in atherogenic diet induced hyperlipidemic rats. Group-I acted as controls (untreated), Group-II acted as atherogenic diet induced controls, standard Hypolipidemic drug (Simvastatin 4mg/kg) used for treating Group-III. The Chloroform Extricate of Trianthema portulacastrum were administered orally at 100mg/kg and 200mg/kg doses for Group IV and V respectively. Serum lipid levels were evaluated after oral administration of standard drug and Chloroform extricate of Trianthema portulacastrum (100mg/kg as well as 200mg/kg) respectively at experimental study’s end. With 200mg/kg of Trianthema portulacastrum Chloroform Extricate treatment, significant reduction in serum lipid parameters like VLDL, LDL, triglycerides, total cholesterol levels and increased HDL level were seen hyperlipidemic rats as compared to control statistically. From these results, it is evident that, Chloroform Extricate of Trianthema portulacastrum entire plant treats hyperlipidemia and improves the liver lipid profile.

Keywords:

Atherogenic diet, Trianthema portula castrum, Hypolipidemic activity, simvastatin.