Synthesis and characterization of acetylation of supra molecular dendrimers

Khambete Hemant*, Jain Sanjay, Prachand Sumeet, Ajay Kumar Shukla, Jain C. P.

Medi-Caps University, Indore, Madhya Pradesh, India

ABSTRACT

Supra molecular dendrimers have emerged as one of the most interesting themes for researchers work as a result of unique functional architecture and macromolecular characteristics. The main drawback of Supra Molecular dendrimers is, due to presence of –NH2 group at the surface, it causes hemolytic toxicity and hence toxic for the blood cells. In this article, we have systematically modified the surface groups of amine-terminated Supra Molecular dendrimers with acetyl groups. The reported methods of Acetylation are very time consuming and multistep which require large amounts of chemicals. In present work we have synthesized Acetylation Supra Molecular dendrimers using 1-ethyl 3- [3-(dimethylamino) propyl] carbodiimide (EDC) as a cross linking agent. The Acetylated dendrimers were evaluated by color reaction, UV, FT-IR, DSC, Size distribution, NMR and ESI Mass Spectra studies and compared with standard data. The absolute molecular weight and molecular weight distribution of 4.0 G and Acetylated Supra Molecular dendrimers were determined respectively by Size distribution and ESI Mass Spectra respectivel. The results revealed that our approach for Acetylation gives considerable amount of Acetylation, cheap, elimination for ganic solvent, requires less time duration and hence gives a better option for Acetylation of dendrimers.

Keywords:

Dendrimers, Etylenediamine, Acetylation, 1-ethyl 3-[3-(dimethylamino) propyl] carbodiimide (EDC), Surface Properties