Micro and nanoparticles for the delivery of growth factors in diabetic wounds

Sanju S, Vyshnavi Tallapaneni, Sriram Narukulla, Divya Pamu, Lavanya Mude, Veera Venkata Satyanarayana Reddy Karri*

JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India

ABSTRACT

Diabetic wound (DW) is one of the leading complications of diabetes patients with a long history. It also puts an economic burden on people recovering from injuries to manage medication. The critical factors in the treatment of DW are infection, inflammation, and low oxygen level. Since these non-healing injuries are linked to the extended recovery process, current treatments are studied only for a short period. The areas covered in this article are an overview of DM, Pathophysiology of DW, stages of wound healing (Hemostasis, Inflammation, Proliferation, Maturation), the role of growth factor in diabetic wound healing, advantages of micro and nanoparticles over other drug delivery systems and micro and nanoparticles for the delivery of growth factors with different studies.

Keywords:

Diabetic Mellitus, Pathophysiology, wound healing, diabetic wounds, Growth factors, Micro and Nanoparticles