Synthesis and antimicrobial evaluation of some new benzthiazole oxime ether derivatives

Sachin V Patil*, Deepak R Nagergoje, Arun G Dholi, Manjusha B Suryavanshi

HPT Arts and RYK Science College, Nashik, Maharashtra, India

ABSTRACT

Some new oxime ether derivatives containing benzthiazole heterocyclic nuclei are synthesized. The reaction of 2-mercapto benzthiazole with α-halo ketones followed by reaction with hydroxylamine gave oxime derivatives which on reaction with alkyl halides viz. ethyl chloride, n-propyl chloride, and n-butyl chloride in absolute ethanol afforded the target compounds 4a-l. The structure of all the synthesized compounds was confirmed by spectroscopic methods like mass and NMR. All compounds after structural confirmation were tested for biological activities.

Keywords:

Oxime ether derivatives, 2-mercapto benzthiazole, ?-halo ketones, Alkyl halides, Biological activity