Optimized fast disintegrating tablets, boosted oseltamivir phosphate orally fast disintegrating tablets

Peeush Singhal, Piyush chamola, Vijay Jyoti Kumar, Sarvesh Kumar, Abhiram Rout

Gurukul Kangri (Deemed to be University), Haridwar, Uttarakhand, India

ABSTRACT

Background Around 33% of the populace (fundamentally pediatric and geriatric) has gulping hardships, bringing about helpless consistence with oral tablet drug treatment which prompts decreased in general treatment viability. For this explanation, tablets that can quickly break down or deteriorate in the oral cavity have drawn in a lot of consideration. Objective research was designed to develop and evaluate boosted orally fast disintegrating tablets (OFDT) for oro-buccal drug delivery of oseltamivir phosphate. Methods In the present study six formulations of mouth dissolving tablet of oseltamivir were prepared by direct compression method using SSG as a super disintegrating agent with lactose, talcum, mannitol, SLS and starch. The prepared tablets were then subjected to various evaluation parameters. Results every one of the outcomes was observed to be inside satisfactory reaches. The formulation F6 manufacturing utilizing SSG 50mg and SLS 10mg showed the higher medication content (98%), while the formulation F2 showed the least medication content (92%). It was seen that with the increment in SSG concentration, the medication content was additionally increased. SEM concentrate on showed request of expanding unpleasantness of tablet surface is F1

Keywords:

Oseltamivir Phosphate, Mouth Dissolving Tablet, Scanning Electron Microscopy, Super Disintegrating Agent