Study on lipoprotein (a) and apo-lipoprotein ratio associated with low grade inflammation in coronary artery disease

Shivasekar Meera*, Thirunavukkarasu Jaishankar, Vinodhini V M

SRM Medical College Hospital & Research Centre, SRMIST, Tamil Nadu, India

ABSTRACT

Coronary artery disease is a major cause of mortality and morbidity in India. Lipoprotein (a) is a heterologous type of plasma lipoprotein particle with a neutral lipid core and a protein component composed of Apolipoprotein B subunits that are covalently bound to a unique protein known as Apolipoprotein (a). Lipoprotein (a) acts as a pro-inflammatory mediator and may increase the formation of plaque lesions in atherosclerosis. Elevated serum Lipoprotein (a) levels are associated with an increased risk of coronary artery disease. This study aims to assess the level of lipoprotein (a) and Apo-lipoprotein ratio along with highly sensitive C-reactive protein in Coronary artery disease and Coronary artery disease subjects with diabetes patients. This cross-sectional study was conducted in SRM Medical College Hospital and Research Centre on Patients appearing the Department of Cardiology and Medicine. The study was conducted on 300 Patients in age group of ≤55years. After an overnight fasting, blood samples were taken for lipid profile and analyzed for Lipoprotein (a), Apo-lipoprotein B, Apo-lipoprotein A1, highly sensitive C- reactive protein and Glycated hemoglobin. For Statistical analysis, Analysis of variance and Pearson's correlation was used. Mean levels of Lipoprotein (a), Apo-lipoprotein B, and hs-CRP showed a significant increase in Coronary artery disease and Coronary artery disease subjects with diabetes compared to the control (p <0>

Keywords:

Apo lipoprotein, Coronary artery disease, Low-Grade Inflammation, Inflammatory marker