Development of novel substituted indole molecules as potential NAV1.7 inhibitors

Sonvane Sameep*,Lonikar Nitin, Bhusnure Omprakash

Channabasweshwar Pharmacy College, Latur, Maharashtra, India

ABSTRACT

Pain is often defined as a single form of the nervous system for abnormal things in the human body. Neuropathic pain is a type of pain that is a consequence of nerve damage and usually, it is a chronic type. Sodium Channel 1.7 (Nav 1.7) is an upcoming target for neuropathic pain management. Several heterocyclic compounds are reported for potentials against neuropathic pain. 24 different heterocyclic derivatives from substituted indole class were synthesized and virtually analyzed against Nav 1.7 for inhibition potential. The developed substituted indole was confirmed via spectral analysis and showed excellent binding ability with Nav 1.7, which can be further explored for biological activity for the development of potential Nav 1.7 inhibitors with excellent activity against Neuropathic pain.

Keywords:

Pain, Neuropathic pain, Indole, Docking.