Fabrication and characterization of ?-cyclodextrin-based nano sponges for delivery of Abiraterone acetate

Barrawaz Aateka Yahya*, Abubakar Salam Bawazir, Sana Saffiruddin Shaikh, Mohammad Hasan Dehghan, Mohammed Abdul Jalil

Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra. India

ABSTRACT

Abiraterone acetate is a steroidal progesterone derivative that inhibits the enzymes CYP17A1, CYP11B1, and the androgen receptor antagonist. It is clinically used in adrenal, testicular, and prostatic cancer. Abiraterone has limited use, due to poor water solubility and low oral bioavailability (

Keywords:

Abiraterone acetate, ?-cyclodextrin nano sponges, Solubility, bioavailability