Formulation development and characterization of in-situ gel for ophthalmic formulation containing gentamicin sulphate and betamethasone

Vidya K Kakad, Prashant S Malpure, Prashant L Pingle

Matoshri College of Pharmacy, Eklahare, Nashik, Maharashtra, India

ABSTRACT

Drug delivery to ocular mucosa is associated with great possibilities but also with many obstacles. Ocular residence time is shortened as a consequence of rapid elimination from corneal surface by the lachrymal flow. In situ gelling systems of Gentamicin Sulphate and Betamethasone Sodium Phosphate have been developed. Formulations were prepared by using Poloxamer 407 along with HPMC K15M. The formulations were evaluated for appearance, pH, drug content and gelation studies, �R. All formulation showed sustained drug release for a period of 8 hrs. Formulations were also studied for stability at refrigerated conditions. Formulation showed good stability and no change in any physical characteristics on storage up to 3 months. Formulation optimization is an area of research that involves studying the interaction between different variables, such as viscosity, CDR and gelling time of a solution. The statistical approach for formulation optimization is useful tool, particularly when two or more variables are to be considered at the same time. Overall, a stable in situ gelling system of Gentamicin Sulphate and Betamethasone Sodium Phosphate had been successfully developed using polymers like HPMC K 15 M and Poloxamer 407 which is stable and showed enhanced residence time with good gelling time and capacity.

Keywords:

Ophthalmic, Gentamicin Sulphate, Betamethasone, Poloxamer 407