Synthesis and screening of antimicrobial and antioxidant activities of 4-(1-alkylindol-3-yl)-6-(substituted phenyl) pyrimidin-2-ol derivatives

Sunil Kumar, Ritika

Guru Jambeshwar university of Science and Technology, Hisar, Haryana, India

ABSTRACT

In seek of effectual antimicrobial and antioxidant agents, a sequence of novel derivatives of indole clubbed with pyrimidine were synthesized. The synthesized derivatives were distinguished by different technique such as IR, 13C NMR, 1H NMR, and Mass spectroscopy. The antimicrobial evaluation of (1-20) was done by tube dilution method against both gram (+) and gram (-) bacteria. The Gram-positive bacteria were Bacillus subtilis and Staphylococcus aureus and Gram-negative strains were Escherichia coli and Pseudomonas aeruginosa. Candida albicans and Aspergillus Niger were used for antifungal activities. Compounds 13, 14, 15, 16 and 19 exhibited promising results of antimicrobial activity with their different MIC values. The potential of the synthesized compounds was also determined by their antioxidant activity by 2, 2-diphenylpicrylhydrazyl method. Antioxidant screening results found compounds 14 and 16 to be the most active compounds.

Keywords:

Synthesis, Antibacterial Activity, Antifungal Activity, Antioxidant activity, Indoles.