In vivo biological evaluation of some benzamide derivatives as potential antidiabetic agents in streptozotocin induced diabetic model

Kazi Asim, Chatpalliwar Vivekanand

S.N.J. B’s S.S.D.J. College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, India

ABSTRACT

Diabetes Mellitus (DM) is a chronic health illness that is caused by a number of geanetic and/or environmental factors. Type 2 diabetes mellitus (T2DM) accounts for more than 95 percent of all instances of diabetes in adults. According to the World Health Organization, India is one of the epicenters of the global diabetes epidemic, and it has the second highest number of diabetics in the world, with a population of over 900 million people (about 69 million people as of 2015).In present study, in vivo antidiabetic activity of some benzamide derivatives have been performed in STZ-nicotinamide-induced diabetic model in rats. The antidiabetic potential has been determined by estimating different serum biochemical and antioxidant parameters. Amongst all the tested molecules, compound 5h demonstrated significant antidiabetic and antioxidant potential when compared to the metformin-treated group. Compound 5h possesses cloprothiazole substitution with benzamide nucleus. It was concluded that compound 5h can be treated as a lead molecule for the design and development of novel antidiabetic agents.

Keywords:

T2DM, Streptozotocin, Benzamide, Diabetes, Rats