Synthesis, characterization, antimicrobial and anticancer evaluation of (E)-N'-benzylidene-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide derivatives

Mohan Verma, Prabhakar Kumar Verma

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

ABSTRACT

The synthesis of a novel family of pyrimidine derivatives has been completed. Infrared–infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectrum data were used to describe these pyrimidine derivatives. All the compounds were evaluated for their in vitro antimicrobial activity against Gram negative strain (Escherichia coli) and Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger) and anticancer potential against Human breast cancer cell line (MCF-7). Results of antimicrobial and anticancer study revealed that compounds (E)-N'-(3-nitrobenzylidene)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (4) and (E)-N'-(3-chlorobenzylidene)-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (10) were found to be the most potent antimicrobial and anticancer agents respectively.

Keywords:

Pyrimidine, Anti-microbial activity, Anti-cancer activity, Benzaldehyde, Pyrimidine derivatives.