Fabrication and evaluation of nanosponges of besifloxacin hydrochloride for ocular drug delivery

Mousumi Kar Pillai*, Preeti Jain, Sujit Pillai

Faculty of Pharmacy Medi-Caps University, Indore, India

ABSTRACT

The aim of the study was to fabricate and evaluate drug loaded nanosponges for ophthalmic drug delivery in a controlled manner for effective therapy. The nanosponges were formed by anionic polymerization of Besifloxacin hydrochloride with ethyl cellulose as a polymer, in presence of polyvinyl alcohol as surfactant. Besifloxacin HCl loaded ethyl cellulose nanosponges were formulated at different rpm i.e 1000 ,1200, 1500, 1800,2000,3000 & 3500 to check the best outcomes. This change in rpm results in different particle size, entrapment efficiency and in vitro release. The selected formulations were evaluated for their antibacterial effect and due to the sustained property of polymer and surfactant property of polyvinyl alcohol, formulated nanosponges showed enhanced antimicrobial study.

Keywords:

Nanosponges, Besifloxacin Hydrochloride, Controlled release, Ethyl cellulose, Polyvinyl alcohol.