Characterization of nano particles ethanol extract of guava (Psidium guajava) fruit with variation of chitosan-alginate

Siti Chunaeni, Sri Winarsih, Elmiawati Latifah, Widarika Santi Hapsari

Department of Pharmacy, Muhammadiyah University of Magelang, Magelang, Indonesia.

Refer this article

Siti Chunaeni, Sri Winarsih, Elmiawati Latifah, Widarika Santi Hapsari, 2022. Characterization of nano particles ethanol extract of guava (Psidium guajava) fruit with variation of chitosan-alginate, Journal of medical pharmaceutical and allied sciences, V 11 - I 3, Pages - 4777 - 4780 Doi: 10.55522/jmpas.V11I3.2506.

ABSTRACT

The ethanol extract of Guava (Psidium Guajava) fruit is known to have strong antioxidant activity so that it has the potential to be developed into a nanoparticle delivery system. The purpose of this study was to determine the effect of variations in the concentration of chitosan - alginate polymer on the physical characteristics of guava fruit extract nanoparticles (Psidium Guajava). Guava Fruit Extract was formulated in the form of nanoparticles by ionic gelation method with variations in the concentration of chitosan:alginate polymer, namely 0.5% : 0.5% (F1), 0.75% : 0.5% (F2), and 1% : 0.5% (F3). The test parameters include the percentage of transmittance. The optimal formulation is based on the level of clarity of the solution and the percentage of transmittance obtained in the formulation ratio of 0.75%: 0.5% (F2), with an average transmittance of 91.9%. Based on the results of the research that has been done, it can be concluded that guava fruit extract can be formulated in nanoparticle size with varying physical characteristics depending on the concentration of chitosan and alginate used.

Keywords:

Nanoparticles, Chitosan, Alginate, Guava Extract

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